& Bull, F
As was previously discussed, it was unclear whether peripheral macrophages would eventually differentiate into bona fide microglia and thereby assume the exact physiological roles of microglia in the CNS
The exact mechanisms of IIM pathogenesis remain unknown, but it is widely believed to result from the interplay of genetic, environmental, immune, and non-immune factors (endoplasmic reticulum stress, oxidative stress, abnormal autophagy regulation, hypoxia, and angiogenesis) [221]
Shah, R., Farmer, L
By the way, you can make your own sauerkraut if you really are motivated
Most of the freshwater in Canada flows north into the Arctic Ocean or into Hudson Bay, while most Canadians live close to the border with the US, and so only a fraction of that fresh water is actually available