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Gholizadeh F, Mokarram P, Dastgheib S, Rahpeima Z

Doss GA, Baillie TA

Early concentrations of paracetamol in the brain (33) appear to be well-timed with the period of the rising concentration in various brain structures (33) and coincide with the noted brain damage and with the appearance of generalized seizures in the present study

Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects