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In vitro studies have inconsistent findings, which is likely due to use of various flavorants and different types of cells studied, as some e-cigarette aerosol chemicals have been found to be pro-inflammatory while others have anti-inflammatory effects, with different cells having different responses to the same aerosol(25)

There were no significant differences in clinical variables across groups, except for the TCQ score, which was significantly higher among those who quit smoking, indicating a greater reduction in craving within this subgroup

There are no deep psychological appeals

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To discourage smokers from quitting, companies redesigned their cigarettes to seem safer

7.25 billion packs P= $ per pack b