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Circulation 134(23):e579e646 Hazebroek M, Dennert R, Heymans S (2012) Idiopathic dilated cardiomyopathy: possible triggers and treatment strategies

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To interrogate the functional relationship between SLC7A11 and cellular sensitivity to APR-246, we firstly knocked down SLC7A11 in JH-EsoAd1 p53 KO (endogenous mut-p53 was knocked out using CRISPR/Cas9) and parental H1299 p53 Null cells