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USP25 is also implicated in inflammation, and it has been found to facilitate removal of Lys63-linked ubiquitin chains from tumor necrosis factor-receptor associated factor 5/6 (TRAF5/6), Usp25 -deficient mice show higher sensitivity to IL-17 dependent inflammation and autoimmunity (Zhong et al., 2012)

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In a study that enrolled 170 patients with symptomatic persistent atrial fibrillation, pre-treatment with intravenous potassium/magnesium improved the success rate of achieving conversion to a normal heart rhythm (Sultan 2012)

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Their multifaceted roles underscore their significance in protecting biological systems from chemical insults and maintaining physiological balance.