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g Using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS I) tool8 (Supplementary file Table 2)

We compared differences in nicotine bioavailability between the Test product and each Reference product as follows: (1) the P -value for the 2-sided test of Test versus Reference paired difference for the log-transformed parameter C max was assessed against a significance level of 0.0125

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