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Fission has the advantage of producing more mitochondria and therefore more ATP, which may be beneficial in diseases involving energy depletion of which asthma is one (Trian et al., 2007

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An exciting recent development has been the discovery of itaconate as an anti-inflammatory metabolite which inhibits the succinate-hypoxia-inducible factor-1 axis (Lampropoulou et al., 2016)