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Lowered histological injury scores

Two common polymorphisms C677T (rs1801133) and A1298C (rs1801131) reduce enzyme activity, leading to elevated homocysteine and impaired methylation

Uric acid crystals can build up in multiple joints, but gout attacks are more common in lower limb joints such as the knees, ankles, and particularly the base of the big toe

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10.1016/j.tips.2011.08.003 Trends Pharmacol