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For the targeted sulfur metabolite quantification approach, the previously established LC-MS conditions were applied 99 with selected reaction monitoring (MRM) using an Ultimate 3000 UPLC system coupled to a Thermo Finnigan TSQ Quantum equipped with HESI (Thermo Fisher Scientific, Waltham, MA)

As an engineered analogue, cagrilintide is designed to mimic key receptor-binding properties of native amylin while incorporating structural modifications that extend its activity and stability in experimental systems

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GPx-2 is the major isoform in the lungs and its basal or inducible expression is dependent on Nrf2