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Related mode-of-action work has evaluated changes in body weight, fat mass, lean mass, and feeding behavior in controlled models, helping researchers explore how amylin pathway activation reshapes whole-body metabolic phenotypes [4]

doi: 10.1212/WNL.0000000000004606 143 VenturaA

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Most HSD-catalyzed reactions are mechanistically reversible and can function bi-directionally, although a prominent directionality is observed in vivo as a result of co-factor affinity and cellular redox status