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J Epidemiol Community Health 65 , 497502, doi:10.1136/jech.2009.093823 (2011)

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It is important to note that these products are not safe and contain addictive nicotine, but our scientific evidence shows that they are a better choice for adults than continuing to smoke cigarettes

Activation of nociceptors can also cause central sensitisation via release of neuropeptides from their central terminals, where they enhance synaptic neurotransmission

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