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Types, natural sources and mechanism of action of antioxidants An AOX is a natural substance that provides protection to the living cell against oxidative damage and deleterious effects of ROS ( Enzymatic AOXs include glutathione (GSH) peroxidase, glutathione reductase, catalase (CAT) and superoxide dismutase (SOD) (2427), carotenoids (e.g., beta-carotene, lycopene) (28), polyphenols (29), and trace elements like selenium and zinc (24, 30)

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Dopaminergic neurons in the substantia nigra pars compacta release dopamine, which binds to D1 receptors in the direct pathway to excite motor-promoting signals and to D2 receptors in the indirect pathway to suppress inhibitory signals [3,4]

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While the CAT, GSH and SOD values were lower in the refractory epilepsy group compared to the control group, the MDA values were higher in the refractory epilepsy group (Figs

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