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It was discovered through high-throughput screening followed by lead optimization and was subsequently characterized as a potent and selective inhibitor of the GlyT1 transporter, with an IC 50 of 3040 nM (Pinard et al

Epub 2020 Nov 18

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Transketolase, PDH, and mRNA levels are decreased by thiamine deprivation (85)

Is Adamax approved by the FDA