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Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

A widely cited study by Kraus and colleagues used genetic knockdown in mice

The motion creates flow patterns that gradually dissolve powder without the violent forces shaking produces

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8 weeks (1 vial): 3 mL 1 10 mL bottle 12 weeks (2 vials): 6 mL 1 10 mL bottle 16 weeks (4 vials): 12 mL 2 10 mL bottles Alcohol Swabs: One for the vial stopper + one for the injection site each administration day

FAQs What is BPC-157