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Within experimental models, it is commonly investigated for its interaction with NNMT-associated pathways and molecular signalling mechanisms

Exogenous MOTS-c doubled running capacity in mice and reversed age-related physical decline by activating the AMPK/PGC-1alpha pathway and directly binding casein kinase 2 (CK2) in skeletal muscle

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When RGD-coated intramedullary nails were inserted into the tibia of male adult Wistar rats, the outcome was increased new bone formation [148]