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However, chronic high cortisol levels can lead to increased plaquing on your coronary arteries, immune system dysfunction, impaired cognitive function, decreased mitochondrial biogenesis (causing fatigue) and put you at greater risk for cancer

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As ionic strength increases (adding salts), this repulsion is shielded, which in some cases can lead to increased aggregation or precipitation of the peptide (especially if the peptide has hydrophobic patches)

Additionally, tirzepatide has undergone cardiovascular outcomes trials, which assess its impact on cardiovascular events