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While GTs initiate extracellular GSH breakdown, the primary intracellular degradation pathway is now thought to be mediated by the cationic transport regulator homolog (ChaC)-like family of -glutamylcyclotransferases (GCT) ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)

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Finally, we report total GSH values in the present study, and acknowledge the significance in understanding the contribution of the reduced (GSH) and oxidized (GSSG) forms of GSH to the overall blood level observed and will address this in the future

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