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Since PM reduced the amount of tobacco when including the additives to maintain the mass of the cigarette constant, presenting the results normalized by tobacco weight led to even greater increases in the estimated effects of the toxins than we present (in our Figures 24)

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To address increases in e-cigarette initiation due to mental health concerns and encourage cessation public education on the potential for nicotine dependence to exacerbate stress and anxiety is warranted 16

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