In vivo autoxidation of dopamine in guinea pig striatum increases with age
And so, using that definition, I found that you needed longer and longer treatment
This indicates substantial phenotypic heterogeneity and suggests that metabolic factors likely act as potent disease accelerants in genetically or biomechanically susceptible individuals, rather than being universal initiators (34)
Pay attention to any mentions of side effects or how long it took to see results
Milk thistle d.e.(Silybum marianum L Gaertn, fruits)

This effect can increase sympathetic outflow and potentiate the release of norepinephrine from nerve endings, leading to activation of 1 and 1 receptors in the heart and peripheral vasculature, with a consequent rise in blood pressure Blocks presynaptic 2 adrenergic receptors Indications: Rarely used Sometimes used in the treatment of orthostatic hypotension because it promotes norepinephrine release through blockade of 2 receptors in both the central nervous system and the periphery There is some evidence that it may be possibly effective in treating erectile dysfunction & SSRI related sexual dysfunction in both men & women by unclear mechanisms (NIH Medlineplus) Has been suggested to have aphrodisiac properties Side Effects: Yohimbine exerts a stimulating action on the mood and may increase anxiety Major drug Interactions: Yohimbine can reverse the antihypertensive effects of an 2 receptor agonist such as clonidine, a potentially serious adverse drug interaction References: Biaggioni I (2021): Adrenoceptor Antagonists (Chapter 10)
