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Common mild effects: Temporary flushing or warmth at infusion site (typically brief) Mild headache in some patients at higher doses Rare nausea Important clinical considerations: Patients with asthma should be evaluated prior to IV glutathione because inhaled glutathione has been associated with bronchospasm in some asthmatic individuals

Endogenous APD is considered an autoimmune condition because someone who has APD reacts to progesterone when their immune system mistakenly identifies progesteronea hormone naturally produced by the body, with peak levels around day 21 of a 28-day menstrual cycle as a harmful substance

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30 Three of the four RCTs of B12 alone used oral B12 (1000 g per day) and one used i.m