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In patients with rheumatoid arthritis (RA), however, Nrf2 dysfunction leads to exacerbated oxidative damage and inflammatory responses

Simple rule: start conservative, re-test in a few weeks, and adjust to your objective labs + how you feel

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Notably, in RA patients with low disease activity, a 12-week course of low-dose sirolimus (0.5 mg every other day) also exhibited a favorable safety profile, elevating Treg levels and enhancing clinical outcomes without evidence of toxicitiessuch as hemorrhagic cystitis or liver fibrosisthat are associated with certain conventional immunosuppressive agents (142)

Neutrophil: a cell with many roles in inflammation or several cell types

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