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Mechanistically, TGF- reduces GSH synthesis by repressing glutamate-cysteine ligase (GCL), the rate-limiting enzyme for GSH biosynthesis

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Biomolecules 9(8):125 Saracyn M, Zdanowski R, Brytan M, Kade G, Nowak Z, Patera J, Dyrla P, Gil J, Wakowicz Z (2015) D-Galactosamine intoxication in experimental animals: is it only an experimental model of acute liver failure

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In line with this, SST promotor methylation is increased in CRC, associating with reduced expression levels [69, 93, 95]

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