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This special design makes them very hydrophilic and helps to avoid unwanted interaction with mucus or proteins 182,183

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In some embodiments, the lipid-based drug delivery formulation or composition comprises a water-soluble preservative wherein the preservative is a benzethonium salt (e.g., benzethonium chloride), benzoic acid, and/or a benzylkonium salt (e.g., benzylkonium chloride)

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