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It was suggested that polymorphisms of glutathione transferases (Ile105Val polymorphism of the GSTP1 gene), ATP binding cassette transporters, OCT2, cytochrome P450 enzymes, polymorphism of ABCC2 (ATP binding cassette subfamily C member 2), and AGXT (alanine glyoxylate aminotransferase) may be involved in the development of OIPN [44,45,46,47,48,49,50]
They have long been known to be excellent radical scavengers, endowed with strong metal chelating ability 112
S.HernandesM
3-NT) and oxidative DNA damage (8-oxo-deoxyguanosine
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Enzymes involved in GSH biosynthesis and function like -glutamyl-cysteine ligase and glutathione synthetase are completely dependent on ATP and require magnesium as a cofactor (Bani Younes et al., 2020
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