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GLP-1 receptor (GLP-1R) activation Stimulates insulin release and suppresses glucagon secretion Delays gastric emptying Provides central appetite regulation Exhibits biased signaling favoring cAMP over -arrestin recruitment sustained receptor expression and enhanced insulin secretory capacity Benefits include: \Weight Loss: Up to 22.5% reduction in body weight

doi: 10.1016/j.ghir.2005.05.002 54 SaukkonenTAminRWilliamsRMFoxCYuenKCWhiteMAet al

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