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This article reviews the distinguishing features of 4 severe drug rashes, summarized in Table 1: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and drug-induced vasculitis

Mitochondria Mitochondria are also the site of generation of harmful ROS, like H 2 O 2 and O 2 (Navrot et al., 2007), though in a smaller scale

Diet composition can influence health markers, including cardiac-related measures in healthy dogs, which is why food choice matters

It is not intended for human consumption, veterinary use, diagnostic procedures, cosmetic use, therapeutic applications, or medical treatment

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On the other hand, gut microbiota (GM) have shown to be able to regulate vitamin A pharmacokinetic profile and immunomodulation functions [10, 12]