Impact of selenium deficiency on inflammation, oxidative stress, and phagocytosis in mouse macrophages
doi: 10.1002/ana.22126
The value of GSH as an immunopharmacologic agent is that it can finetune immune response in a disease-dependent and redox state-dependent manner which differs from typical broad-effect immunosuppressive treatments (Figure 3)
Several studies have shown that quercetin can suppress the expression of inflammatory mediators and cytokines such as COX-2, NO, NF-kB, prostaglandin E2 (PGE2), iNOS, TNF-, IL-1, and IL-6 that are generated through the LPS-TLR4 pathway (159) ( Supplementary Table 1 )
GNF triggered ferroptosis in TGF-1-treated melanoma cells by activating the p53/SLC7A11/GPX4 axis (Wang et al., 2020)
Interestingly, SFN did not increase the percentage of cells expressing pNRF2 (S