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Additionally, conventional antioxidants such as -tocopherol (vitamin E), NAC, and butylated hydroxytoluene (BHT) have shown similar radical-scavenging capabilities and can inhibit ferroptosis in a manner comparable to ferrostatins and liproxstatins (416)

In further embodiments, the carrier is polyethylene glycol

Participants receive a single administration of the investigational drug, starting from a low dose level derived from preclinical evidence and set as the MRSD

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To analyze MRS data, we used the LCModel with a basis set of simulated spectra comprising the following 20 metabolites: Aspartate (Asp), phosphocholine (PCh), creatine (Cr), phosphocreatine (PCr), GABA, Gln, Glu, glutathione (GSH), glycine (Gly), mI, lactate (Lac), NAA, scyllo-inositol (Scyllo), taurine (Tau), glucose (Glc), N-acetylaspartylglutamate (NAAG), glycerophosphocholine (GPC), phosphorylethanolamine (PE), Serine (Ser), and MM (Fig

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