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(2018) 172:13546.e9

2.3 Amino acid metabolism and antioxidant systems regulate ferroptosis Abnormal amino acid metabolism leads to the inactivation of antioxidant systems, and the accumulation of lipid peroxidation products is regulated by antioxidant systems, which are considered critical determinants of whether ferroptosis occurs

DFS, Disease-free survival

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Methotrexate-induced alteration of renal Aquaporins 1 and 2, oxidative stress and tubular apoptosis can be attenuated by Omega-3 fatty acids supplementation