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This effect is primarily mediated by an increase in the phosphorylation of insulin receptor substrate 1 (IRS1) and a concomitant inhibition of Akt phosphorylation, a crucial component of the insulin signaling pathway

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Downstream signaling from RTK activation: Receptor binding triggers autophosphorylation recruiting adaptor proteins initiating multiple pathways

Tirzepatide (GLP-1/GIP) Tirzepatide is a first-in-class dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist, providing synergistic metabolic effects for diabetes and obesity research

1995 Oct 26;333(17):110610