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Cancer 23 , 7894 (2023)

one that binds too loosely offers no advantage over a free ion and can catalyze damaging redox reactions

We hypothesize that these enzymes will have a decreased expression in NEC, leading to higher amounts of ROS and increased proclivity to NEC

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In parallel, the effect of the drugs were simulated using an adapted version of the singleGeneDeletion of the COBRA toolbox [28] (Drug Deletion function): Therefore, DrugBank v5.1.3 [29] was mined to identify 1175 drugs inhibiting metabolic genes (genes present in Recon 2.04) and their targets that were then used as input for the Drug Deletion function

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