Liu N, Zhen Z, Xiong X, Xue Y
Studies demonstrate that periodic administration in aged animal models extends healthspan, improving physical performance, organ function, and resistance to age-related diseases (2, 3)
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The mechanism involves stimulating over 300 different genes associated with tissue repair and remodeling, fibroblast activation and collagen synthesis, epidermal basal stem cell viability, an anti-inflammatory effect, an antioxidant effect and stimulation of microvascular growth
The results showed a significant increase in skin density and thickness, with a 67% reduction in wrinkle volume and improved elasticity, as measured by ultrasound and profilometry (Leyden et al., 2002)