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Impurities can include truncated peptide sequences, synthesis byproducts, and aggregated proteins that interfere with receptor binding or trigger immune responses in animal models

LSVT/LOUD gives the potential of treatments focused on a single target, encouraging cross-system improvement and delivery systems in line with principles of neural plasticity [115]

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(2007) Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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doi: 10.1007/s00296-011-1984-x 135 MulhearnBMarshallLSutcliffeMHannesSKFonsekaCHussellTet al