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Because human cells cannot store any significant amount of folate but the liver can store 3-6 years worth of B12, folate deficient megaloblastic anemias manifest very quickly, whereas B12 deficient anemias take considerably longer to manifest

Notably, induction of inflammatory mediators also occurs in BBB ECs, suggesting the progression of inflammation from glia to cerebral microvessels

Perimenopause Before going through menopause at the end of the female reproductive cycle, a woman enters the perimenopausal stage

doi: 10.1007/s12640-021-00417-y