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Mitochondria are the main source of ROS in response to oxidants 7 , and play dominant roles in apoptosis 53,54,55,56,57,58 and necrosis in RPE cells 59,60

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Nuclear receptor agonists, particularly FXR modulators, have demonstrated efficacy in attenuating bile acid cytotoxicity, enhancing hepatobiliary excretion, and mitigating bilirubin accumulation [54]

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Neuroinflammation 14, 63