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The most common melanomas in non-White population arise from epithelium-asssociated melanocytes on acral skin (palms, soles, nail apparatus) or mucous membranes and are characterized by an early onset of major chromoscomal rearrangements, such as chromotripsis, with gene copy number changes, including multiple high-level amplifications (8)

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In these cases, artificial tears, punctal plugs, or prescription eye drops to increase tear production may be used

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The severity of the symptoms of type I hypersensitivity ranges from local responses in the respiratory tract (causing rhinitis or asthma), liver (immune-mediated hepatitis), and skin (dermatitis) to severe and potentially life-threatening anaphylaxis, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS)

Planta medica, 55(5), 420422