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Additional examples of otoprotectants include guanosine, guanosine diphosphate, Valacyclovir, 6-mercaptopurine (e.g., Purinethol), thio-deoxyguanosine, and 6-thioguanine (e.g., 6-TG, Tabloid, Lanvis)
Lehmann D, Skrandies W (1980)
Mitochondrial proteomic datasets reveal that adipose depots have distinct respiratory chain compositions and CI regulatory inputs, further supporting the idea that reduced CI function differentially affects distinct adipose tissue depots 52,53
The peptide upregulates genes involved in extracellular matrix synthesis, tissue repair, and cellular proliferation while downregulating genes associated with inflammation, matrix degradation, and cellular senescence
doi: 10.1007/s11011-018-0348-6
Stria of all ages can then be grown under similar treatment conditions as for SGNs and cochleae as described above for the evaluation of otoprotectant agents
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