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However, natural glutathione levels can decrease due to stress, aging, and pollution

doi: 10.1016/j.arr.2022.101619

In addition, previous studies in tilapia demonstrate metabolic dysfunctions, oxidative stress, and thereby compromised immune capacity

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Nrf2 is the principal transcription factor in charge of protecting cells from oxidative stress through the regulation of cytoprotective genes, including the antioxidant GSH pathway, that controls GSH homeostasis by affecting de novo synthesis

Autophagy 19, 20622077