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15 , e1007756 (2019)

Increase to 0.5 mg weekly for the next 4 weeks

GLP-1 inhibits intestinal contractions through mechanisms that may involve the central nervous system via vagal pathways or direct action on central receptors [24], as well as the enteric nervous system by modulating neurotransmission through presynaptic receptors affecting nitric oxide release [25,26]

These are predominantly present in the first eight to twelve weeks and resolve for the majority of participants after the body has adjusted to the compounds effects on gastric motility

Future drugs may target three or more receptors simultaneously

For short-term storage of a few weeks before use, a cool, dark place away from light is sufficient