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McInnes and Schett, 2011

Stage 3 (Moderate) At stage 3, osteoarthritis of the knee becomes more pronounced, with significant cartilage loss and joint deformity

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Introduction The first reports about a plant glutathione S-transferase enzyme (GST, EC 2.5.1.18) appeared in 1970, when it was revealed that a GST catalyzed the detoxification of the herbicide atrazine by its conjugation to the endogenous tripeptide glutathione (GSH, -L-glutamyl-L-cysteinyl-glycine) in sorghum and maize plants (Frear and Swanson, 1) and the nucleophilic GSH, thus tagging the xenobiotic for vacuolar sequestration (Martinoia et al., 1) (Bartling et al., Figure 1 (B) Nucleophilic addition reaction between cinnamic acid and GSH (Edwards and Dixon, (C) Reduction (detoxification) of fatty acid hydroperoxides to corresponding hydroxy derivatives by the peroxidase activity of GST as described by Bartling et al

"The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis"

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