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This mechanism is different from acid-suppressing drugs like proton pump inhibitors (PPIs) or H2 blockers, which reduce acid production but do not affect the LES function directly

Upston JM, Witting PK, Brown AJ, Stocker R, Keaney JF, Jr

The naturally occurring peptide GHK (glycyl-L-histidyl-L-lysine), in its Cu-bound form, supports angiogenesis, remodeling, and tissue repair, has anti-inflammatory and antioxidant properties, and has been shown to improve cognitive performance in aging mice

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These ROS-driven NF-B signaling events in muscle atrophy are summarized in Figure 7