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Additionally, studies have revealed a sort of feed-back loop showing that sleep deprivation, even partial, makes the body even more susceptible to negative effects of toxic exposures

She develops intrahepatic cholestasis (0.4-10% of pregnancies), which has been associated with fatal outcomes from therapeutic acetaminophen doses

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10.1155/2019/5028181 Oxid Med Cell Long

Sofia Antonsson Reg

To contrast this effect, in non-sleep deprived persons, toxic exposures did not produce negative effects to the same degree as that presented in chronically sleep-deprived individuals