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The effect was attributed to microbial metabolites that promoted a more youthful systemic environment (for example, boosting the production of certain short-chain fatty acids and reducing pro-inflammatory cytokines) [121]

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At the same time, HIFU (High-Intensity Focused Ultrasound) is gaining popularity in professional aesthetic clinics and for good reason

Rheumatology 41 , 658665 (2002)

developed a quercetin delivery system encapsulated by chitosan-based nanoparticles (Qu/CS-NPs) through ionic interaction, improving water solubility and stability of quercetin

Scientists then isolated it and created a synthetic version to explore its benefits