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We hypothesized that this lack of effect could be due to the fact that receptor-bound dKLAK-z13 localizes to the luminal side of endosomes, a prediction supported by the endosome-like pattern of fluorescent z13 (Fig

doi: 10.1016/j.phymed.2019.152881

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Together, our findings establish a direct connection among O -GlcNAc signals, de novo nucleotide synthesis and human diseases, including cancer and Arts syndrome