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This result suggested that cystine starvation may induce ferroptosis by both blocking GSH biosynthesis and reducing GPX4 protein level

Nature 408 , 211216 (2000)

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In subacute toxicity studies, high doses (1,600 mg/kg) of the stem bark extract led to elevated liver enzymes and biochemical markers of kidney damage, indicating potential hepatotoxicity and nephrotoxicity with prolonged use (706)

Deragon MA, McCaig WD, Patel PS, Haluska RJ, Hodges AL, Sosunov SA, et al

SIRT1 is a histone deacetylase, which may regulate the transcriptional activity of BMAL1/CLOCK, forming a metabolic feedback loop again between the circadian clock system and metabolism (Nakahata et al., 2009