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Abnormal microglial activation, oxidative stress, and neuronal death are also associated with the progression of the disease

Anti-PD-1 antibodies such as pembrolizumab and nivolumab were included the second set of antibodies to be approved for the treatment of human malignancies, followed by anti-PD-L1 antibodies such as atezolizumab, durvalumab, and avelumab 86

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A molecule that touches several sequential phases, rather than a single step, is consistent with the coordinating signal framing, but it also makes the biology harder to reduce to one clean mechanism and harder to predict when the whole-body copper economy, rather than a walled-off chamber, sets the terms of exposure

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