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In research targeting the c-Met receptor tyrosine kinase (MET), two plant compounds were identified through VS and MD simulation, that is, neogitogenin and samogenin, which have significant binding affinity and show promising inhibitory activity against MET (Elasbali et al., 2024)

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Additionally, further exploration of the role of topiramate in modulating this pathway, particularly its dose-dependent effects, is necessary

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