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They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption
For instance, a GHK-Cu serum with a moderate concentration is often praised for improving skin texture and firmness
The clinical evidence is substantial here are the most significant findings: This study used nanocarrier delivery formulations and VISIA 3D imaging the gold standard for objective skin measurement
Tsou W-L, Burr AA, Ouyang M, Blount JR, Scaglione KM, Todi S V