Do we know if any of them actually had a deficiency
The two are documented differently: the 10 mg vial at 600 mcg per dose (about 16 doses), the 20 mg vial at 250 mcg per dose (about 80 doses)
TB-500 is based on a part of TB4, so it should, in theory, have a similar safety profile, but studies specifically analyzing its safety still need to be conducted
Not during reconstitution, but during the drawing process
Enteroendocrine cells (EECs), the microbiota, and metabolites produced by the microbiota constitute a complex signaling system [13] that involves the enteric plexus, CNS afferents and efferents, and the modulation of numerous brain nuclei like the nucleus tractus solitarius, hypothalamus, thalamus, and many others directly involved in the control of glucose and energy homeostasis [14]
It affects the hands and feet and can have an impact on many bodily processes