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An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

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This association positions 3-HIB as both a pathophysiological marker of metabolic inflexibility and a potential predictor of therapeutic response, with mechanistic studies suggesting its role in impairing endothelial function and promoting cardiac lipotoxicity

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To confirm these predictions, we measured glucose uptake with 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose (2-NBDG) 72 in B6 MZB and FoB